2. Medical Biotechnology

1. Question

4 point(s)

Recombinant therapeutics are safer because:

They induce unwanted immunological responses

Correct Incorrect Correct answer

They do not induce unwanted immunological responses

Correct Incorrect Correct answer

They are cheaper

Correct Incorrect Correct answer

They are easier to store

Correct Incorrect Correct answer

2. Question

4 point(s)

How many recombinant therapeutics have been approved for human use worldwide?

12

Correct Incorrect Correct answer

30

Correct Incorrect Correct answer

50

Correct Incorrect Correct answer

100

Correct Incorrect Correct answer

3. Question

4 point(s)

How many recombinant therapeutics are marketed in India?

30

Correct Incorrect Correct answer

12

Correct Incorrect Correct answer

10

Correct Incorrect Correct answer

25

Correct Incorrect Correct answer

4. Question

4 point(s)

Earlier, insulin used for diabetes was extracted from:

Pancreas of slaughtered cattle and pigs

Correct Incorrect Correct answer

Human cadavers

Correct Incorrect Correct answer

Plants

Correct Incorrect Correct answer

Dogs

Correct Incorrect Correct answer

5. Question

4 point(s)

Insulin consists of two short polypeptide chains: Chain A and Chain B, linked by:

Hydrogen bonds

Correct Incorrect Correct answer

Disulphide bridges

Correct Incorrect Correct answer

Peptide bonds

Correct Incorrect Correct answer

Ionic bonds

Correct Incorrect Correct answer

6. Question

4 point(s)

In mammals, insulin is synthesized as a pro-hormone containing an extra stretch called:

A peptide

Correct Incorrect Correct answer

B peptide

Correct Incorrect Correct answer

C peptide

Correct Incorrect Correct answer

D peptide

Correct Incorrect Correct answer

7. Question

4 point(s)

The main challenge for production of insulin using rDNA techniques was:

Getting the bacteria to produce insulin

Correct Incorrect Correct answer

Getting insulin assembled into a mature form

Correct Incorrect Correct answer

Isolating the gene

Correct Incorrect Correct answer

Purifying the protein

Correct Incorrect Correct answer

8. Question

4 point(s)

In 1983, which American company prepared two DNA sequences corresponding to A and B chains of human insulin?

Genentech

Correct Incorrect Correct answer

Eli Lilly

Correct Incorrect Correct answer

Monsanto

Correct Incorrect Correct answer

Pfizer

Correct Incorrect Correct answer

9. Question

4 point(s)

The chains A and B of insulin were produced separately in E. coli and combined by creating:

Peptide bonds

Correct Incorrect Correct answer

Disulphide bonds

Correct Incorrect Correct answer

Hydrogen bonds

Correct Incorrect Correct answer

Ionic bonds

Correct Incorrect Correct answer

10. Question

4 point(s)

Gene therapy is a collection of methods that allows correction of a gene defect diagnosed in:

Adults only

Correct Incorrect Correct answer

Child or Embryo

Correct Incorrect Correct answer

Animals only

Correct Incorrect Correct answer

Elderly

Correct Incorrect Correct answer

11. Question

4 point(s)

The first clinical gene therapy was given in 1990 to a 4-year-old girl with:

Adenosine deaminase (ADA) deficiency

Correct Incorrect Correct answer

Insulin deficiency

Correct Incorrect Correct answer

Growth hormone deficiency

Correct Incorrect Correct answer

Cystic fibrosis

Correct Incorrect Correct answer

12. Question

4 point(s)

ADA deficiency is caused by the deletion of the gene for:

Adenosine deaminase

Correct Incorrect Correct answer

Adenine deaminase

Correct Incorrect Correct answer

Adenosine demethylase

Correct Incorrect Correct answer

Adenosine dehydrogenase

Correct Incorrect Correct answer

13. Question

4 point(s)

ADA enzyme is crucial for the immune system to function. Its deficiency leads to:

SCID (Severe Combined Immunodeficiency)

Correct Incorrect Correct answer

Diabetes

Correct Incorrect Correct answer

Cancer

Correct Incorrect Correct answer

Anemia

Correct Incorrect Correct answer

14. Question

4 point(s)

In gene therapy for ADA, lymphocytes from the patient are grown in culture and introduced with:

A functional ADA cDNA using a retroviral vector

Correct Incorrect Correct answer

A bacterial ADA gene

Correct Incorrect Correct answer

A plasmid

Correct Incorrect Correct answer

A fungal gene

Correct Incorrect Correct answer

15. Question

4 point(s)

Why is the first gene therapy for ADA not a permanent cure?

The cells are immortal

Correct Incorrect Correct answer

The cells are not immortal and die

Correct Incorrect Correct answer

The gene mutates

Correct Incorrect Correct answer

The virus kills the cells

Correct Incorrect Correct answer

16. Question

4 point(s)

A permanent cure for ADA deficiency could be achieved if functional ADA cDNA is introduced into:

Lymphocytes in adult stage

Correct Incorrect Correct answer

Marrow cells in early embryonic stages

Correct Incorrect Correct answer

Liver cells

Correct Incorrect Correct answer

Blood cells

Correct Incorrect Correct answer

17. Question

4 point(s)

Molecular diagnosis techniques include:

Serum and Urine analysis

Correct Incorrect Correct answer

PCR, ELISA, and Recombinant DNA technology

Correct Incorrect Correct answer

X-ray

Correct Incorrect Correct answer

Ultrasound

Correct Incorrect Correct answer

18. Question

4 point(s)

PCR is useful for detecting:

High amounts of pathogen

Correct Incorrect Correct answer

Very low amounts of DNA/pathogen

Correct Incorrect Correct answer

Proteins only

Correct Incorrect Correct answer

Lipids

Correct Incorrect Correct answer

19. Question

4 point(s)

ELISA is based on the principle of:

Antigen-Antibody interaction

Correct Incorrect Correct answer

DNA-DNA hybridization

Correct Incorrect Correct answer

RNA-DNA hybridization

Correct Incorrect Correct answer

Enzyme-Substrate locking

Correct Incorrect Correct answer

20. Question

4 point(s)

A single stranded DNA or RNA, tagged with a radioactive molecule (probe) is allowed to hybridize to its complementary DNA in a clone of cells followed by detection using:

PCR

Correct Incorrect Correct answer

Autoradiography

Correct Incorrect Correct answer

Electrophoresis

Correct Incorrect Correct answer

Microscopy

Correct Incorrect Correct answer

21. Question

4 point(s)

[NEET 2016] Which kind of therapy was given in 1990 to a four-year-old girl with ADA deficiency?

Gene therapy

Correct Incorrect Correct answer

Chemotherapy

Correct Incorrect Correct answer

Immunotherapy

Correct Incorrect Correct answer

Radiation therapy

Correct Incorrect Correct answer

22. Question

4 point(s)

The pro-insulin has an extra peptide called:

B-peptide

Correct Incorrect Correct answer

A-peptide

Correct Incorrect Correct answer

C-peptide

Correct Incorrect Correct answer

S-peptide

Correct Incorrect Correct answer

23. Question

4 point(s)

Human insulin is being commercially produced from a transgenic species of:

Rhizobium

Correct Incorrect Correct answer

Saccharomyces

Correct Incorrect Correct answer

Escherichia

Correct Incorrect Correct answer

Mycobacterium

Correct Incorrect Correct answer

24. Question

4 point(s)

ELISA stands for:

Enzyme Linked Immuno-Sorbent Assay

Correct Incorrect Correct answer

Enzyme Linked Immuno-Salt Assay

Correct Incorrect Correct answer

Enzyme Load Immuno-Sorbent Assay

Correct Incorrect Correct answer

Enzyme Loop Immuno-Sorbent Assay

Correct Incorrect Correct answer

25. Question

4 point(s)

PCR is used to detect:

HIV in suspected AIDS patients

Correct Incorrect Correct answer

Mutations in genes in suspected cancer patients

Correct Incorrect Correct answer

Both A and B

Correct Incorrect Correct answer

None of these

Correct Incorrect Correct answer

26. Question

4 point(s)

Twisted: In autoradiography, the clone having the mutated gene will:

Appear on the photographic film

Correct Incorrect Correct answer

Not appear on the photographic film

Correct Incorrect Correct answer

Appear distinctively bright

Correct Incorrect Correct answer

Appear blue

Correct Incorrect Correct answer

27. Question

4 point(s)

[NEET 2018] The two polypeptides of human insulin are linked together by:

Disulphide bridges

Correct Incorrect Correct answer

Hydrogen bonds

Correct Incorrect Correct answer

Phosphodiester bonds

Correct Incorrect Correct answer

Ionic bonds

Correct Incorrect Correct answer

28. Question

4 point(s)

Which of the following is NOT a method of early diagnosis?

Serum and Urine analysis

Correct Incorrect Correct answer

PCR

Correct Incorrect Correct answer

ELISA

Correct Incorrect Correct answer

Recombinant DNA technology

Correct Incorrect Correct answer

29. Question

4 point(s)

In the maturation of insulin:

A chain is removed

Correct Incorrect Correct answer

B chain is removed

Correct Incorrect Correct answer

C peptide is removed

Correct Incorrect Correct answer

Disulphide bonds are removed

Correct Incorrect Correct answer

30. Question

4 point(s)

ADA deficiency can be treated by:

Bone marrow transplantation

Correct Incorrect Correct answer

Enzyme replacement therapy

Correct Incorrect Correct answer

Gene therapy

Correct Incorrect Correct answer

All of the above

Correct Incorrect Correct answer

31. Question

4 point(s)

The site of production of ADA in the body is:

Erythrocytes

Correct Incorrect Correct answer

Lymphocytes

Correct Incorrect Correct answer

Blood plasma

Correct Incorrect Correct answer

Osteocytes

Correct Incorrect Correct answer

32. Question

4 point(s)

In Enzyme Replacement Therapy:

Functional ADA is given to the patient by injection

Correct Incorrect Correct answer

Gene is replaced

Correct Incorrect Correct answer

Bone marrow is replaced

Correct Incorrect Correct answer

Insulin is given

Correct Incorrect Correct answer

33. Question

4 point(s)

The first company to market recombinant insulin (Humulin) was:

Genentech

Correct Incorrect Correct answer

Eli Lilly

Correct Incorrect Correct answer

Biocon

Correct Incorrect Correct answer

Pfizer

Correct Incorrect Correct answer

34. Question

4 point(s)

Twisted: If a probe does not bind to the DNA, it indicates:

The DNA is complementary

Correct Incorrect Correct answer

The DNA is mutated/different

Correct Incorrect Correct answer

The probe is defective

Correct Incorrect Correct answer

The film is bad

Correct Incorrect Correct answer

35. Question

4 point(s)

ELISA detects infection by presence of:

Antigens (Proteins/Glycoproteins)

Correct Incorrect Correct answer

Antibodies synthesized against pathogen

Correct Incorrect Correct answer

Both A and B

Correct Incorrect Correct answer

DNA

Correct Incorrect Correct answer

36. Question

4 point(s)

Which technique serves the purpose of early diagnosis?

PCR

Correct Incorrect Correct answer

Serum analysis

Correct Incorrect Correct answer

Urine analysis

Correct Incorrect Correct answer

Clinical observation

Correct Incorrect Correct answer

37. Question

4 point(s)

[NEET 2020] In gene therapy of Adenosine Deaminase (ADA) deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because:

Genetically engineered lymphocytes are not immortal cells

Correct Incorrect Correct answer

Retroviral vector is unstable

Correct Incorrect Correct answer

Gene gets mutated

Correct Incorrect Correct answer

Enzyme degrades

Correct Incorrect Correct answer

38. Question

4 point(s)

Recombinant DNA technology allows the production of:

Safer and more effective therapeutic drugs

Correct Incorrect Correct answer

Toxic drugs

Correct Incorrect Correct answer

Drugs with severe side effects

Correct Incorrect Correct answer

Animal-derived drugs

Correct Incorrect Correct answer

39. Question

4 point(s)

Insulin from animal sources caused:

Allergy in some patients

Correct Incorrect Correct answer

Effective cure without side effects

Correct Incorrect Correct answer

Immediate death

Correct Incorrect Correct answer

Genetic mutation

Correct Incorrect Correct answer

40. Question

4 point(s)

The C-peptide is present in:

Mature insulin

Correct Incorrect Correct answer

Pro-insulin

Correct Incorrect Correct answer

Both

Correct Incorrect Correct answer

Neither

Correct Incorrect Correct answer

41. Question

4 point(s)

To produce human insulin in bacteria, the A and B chain genes were linked to:

LacZ gene

Correct Incorrect Correct answer

Galactosidase

Correct Incorrect Correct answer

Plasmid of E. coli

Correct Incorrect Correct answer

Yeast chromosome

Correct Incorrect Correct answer

42. Question

4 point(s)

Which vector is used to introduce the ADA gene into lymphocytes?

Retrovirus

Correct Incorrect Correct answer

Agrobacterium

Correct Incorrect Correct answer

Bacillus

Correct Incorrect Correct answer

Plasmid

Correct Incorrect Correct answer

43. Question

4 point(s)

The use of PCR in cancer patients is to:

Detect mutations in genes

Correct Incorrect Correct answer

Kill cancer cells

Correct Incorrect Correct answer

Introduce genes

Correct Incorrect Correct answer

Amplify cancer cells

Correct Incorrect Correct answer

44. Question

4 point(s)

A ‘Probe’ is:

A single stranded DNA/RNA tagged with radioactive molecule

Correct Incorrect Correct answer

A double stranded DNA

Correct Incorrect Correct answer

A protein

Correct Incorrect Correct answer

An enzyme

Correct Incorrect Correct answer

45. Question

4 point(s)

Correction of a genetic defect involves delivery of:

A normal gene

Correct Incorrect Correct answer

A mutant gene

Correct Incorrect Correct answer

An enzyme

Correct Incorrect Correct answer

A chemical

Correct Incorrect Correct answer

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