Every Cell Signalling and Immunology question (Unit 4) CSIR-NET Life Sciences has set in its last 11 papers, sorted by topic, with 16 of them solved step by step. Answers follow NTA’s final answer keys.
Unit 4 of the CSIR-NET Life Sciences syllabus, Cell Communication and Cell Signaling, covers host–parasite interactions, cell signalling (receptors, second messengers, kinase cascades), cancer biology, and innate and adaptive immunity. We went through all 11 papers from February 2022 to June 2025 and pulled out every question from this unit.
How much of the paper is Cell Signalling and Immunology?
Across the 11 papers, 95 of the 1,375 Part B and Part C questions (6.9%) came from Unit 4. That ranks it eleventh of the 13 units. 55 of the 95 were 4-mark Part C questions.
| Paper | Part B | Part C | Total |
|---|---|---|---|
| June 2025 | 2 | 3 | 5 |
| December 2024, Shift 1 | 4 | 4 | 8 |
| December 2024, Shift 2 | 4 | 5 | 9 |
| June 2024, Shift 1 | 2 | 7 | 9 |
| June 2024, Shift 2 | 5 | 4 | 9 |
| December 2023, Shift 1 | 4 | 4 | 8 |
| December 2023, Shift 2 | 4 | 7 | 11 |
| June 2023, Shift 1 | 4 | 6 | 10 |
| June 2023, Shift 2 | 3 | 4 | 7 |
| February 2022, Shift 1 | 4 | 4 | 8 |
| February 2022, Shift 2 | 4 | 7 | 11 |
| All 11 papers | 40 | 55 | 95 |
Which Cell Signalling and Immunology topics come up most
Innate & Adaptive Immunity and Cell Signalling together account for 71% of the unit’s questions.
16 solved Cell Signalling and Immunology PYQs
One or two from each major subtopic, from different papers. Try each one before you open the solution.
Which one of the following is the major antibody in the early stages of a primary immune response?
- 1IgA
- 2IgM
- 3IgD
- 4IgE
Show answer and solution
IgM is the first antibody made by naive B cells and dominates the early primary response. It is a pentamer with ten antigen-binding sites, so it binds well even before affinity maturation, and it fixes complement efficiently. IgG takes over later, after class switching. IgA protects mucosa and IgE acts against parasites and in allergy.
The mode of action of cholera toxin in causing diarrhoea is by:
- 1inactivating Gi protein.
- 2continuous activation of adenylyl cyclase.
- 3locking Gs protein in an inactive state.
- 4rapidly hydrolyzing GTP to GDP.
Show answer and solution
Cholera toxin ADP-ribosylates the α subunit of Gs, which stops its GTPase activity. Gs stays GTP-bound, so adenylyl cyclase is switched on continuously. The resulting high cAMP activates PKA, which opens CFTR in intestinal cells. Cl− and water then pour into the gut. Pertussis toxin is the one that inactivates Gi.
Which one of the following mechanisms permits immunoglobulin to be synthesized in either a membrane-bound or secreted form?
- 1Allelic exclusion
- 2Class switch recombination
- 3Differential RNA processing
- 4Codominant expression
Show answer and solution
Answer: (3) Differential RNA processing
Membrane and secreted forms of an antibody come from the same heavy-chain gene. They differ in which 3′ end of the primary transcript is used: alternative polyadenylation and splicing. Splicing in the M1/M2 exons adds a transmembrane tail (the B-cell receptor). Using the upstream poly(A) site gives the secreted tail of the plasma cell. No change in the DNA is involved.
In response to a Wnt signal, β-catenin enters the nucleus and binds to the LEF1/TCF proteins by displacing which one of the following proteins?
- 1CBP
- 2GSK3
- 3Groucho
- 4NEMO
Show answer and solution
Answer: (3) Groucho
Without a Wnt signal, TCF/LEF sits on its target genes bound to the co-repressor Groucho (TLE), keeping them silent. Stabilised β-catenin entering the nucleus displaces Groucho from TCF and recruits co-activators such as CBP and BCL9/Pygopus, switching the genes on. GSK3 acts in the cytoplasmic destruction complex.
Live vaccines are generally used to protect against which one of the following viruses?
- 1Hepatitis A
- 2Hepatitis B
- 3Rabies
- 4Smallpox
Show answer and solution
Answer: (4) Smallpox
The smallpox vaccine is live vaccinia virus, which famously eradicated the disease. Vaccines against hepatitis A and rabies are inactivated whole virus, and the hepatitis B vaccine is a recombinant subunit (HBsAg). Other live vaccines include MMR, varicella, oral polio and yellow fever.
The cytoplasmic domain of the receptor of which of the following proteins does NOT function as tyrosine kinase?
- 1Epidermal growth factor
- 2Platelet derived growth factor
- 3Insulin
- 4Asialoglycoprotein
Show answer and solution
Answer: (4) Asialoglycoprotein
EGF, PDGF and insulin all bind receptor tyrosine kinases. The asialoglycoprotein receptor on hepatocytes is an endocytic lectin. It binds glycoproteins whose terminal sialic acid has been removed, exposing galactose, and carries them into the cell by clathrin-mediated endocytosis for degradation. Its cytoplasmic tail has no kinase activity.
Nitric oxide (NO) acts as intracellular second messenger by stimulating
- 1Phosphodiesterase
- 2Nitric oxide synthase
- 3Adenylyl cyclase
- 4Guanylyl cyclase
Show answer and solution
Answer: (4) Guanylyl cyclase
NO crosses membranes and binds the haem of soluble guanylyl cyclase. This raises cGMP, which activates PKG and relaxes smooth muscle. Sildenafil works by blocking PDE5, which breaks down cGMP. Nitric oxide synthase makes NO; it is not the target of NO.
Which one of the following is NOT required for isotype switching from IgM to IgE?
- 1VDJ recombination
- 2Double stranded break repair
- 3Cell division
- 4T cell cytokines
Show answer and solution
Answer: (1) VDJ recombination
Class switching from IgM to IgE needs T-cell help (CD40L and IL-4/IL-13), cell division, AID-induced double-strand breaks in the switch regions, and their repair by non-homologous end joining. V(D)J recombination happened much earlier, during B-cell development in the bone marrow. Switching keeps the same VDJ and changes only the constant region.
In the thymus of a normal mouse, positive selection of T cells is based on recognition of which of the following?
- 1foreign antigens in association with self-MHC molecules.
- 2self-antigens in association with foreign-MHC molecules.
- 3self-antigens in association with self-MHC molecules.
- 4foreign antigens in association with TLR ligands.
Show answer and solution
Answer: (3) self-antigens in association with self-MHC molecules.
In the thymic cortex, thymocytes whose TCRs can bind self-peptide on self-MHC with at least weak affinity get a survival signal. That is positive selection, giving MHC restriction. Those that bind self-peptide–MHC too strongly are removed later by negative selection, giving tolerance. Foreign antigens play no part in either.
Kaposi’s sarcoma is caused by
- 1Epstein-Barr virus
- 2HIV and HHV-8
- 3HTLV type1
- 4HPV
Show answer and solution
Answer: (2) HIV and HHV-8
Kaposi’s sarcoma is caused by human herpesvirus 8 (KSHV). It occurs mainly in people with HIV-driven immunosuppression, which is why it is an AIDS-defining cancer, so NTA’s answer pairs HIV with HHV-8. EBV causes Burkitt’s lymphoma and nasopharyngeal carcinoma, HTLV-1 adult T-cell leukaemia, and HPV cervical cancer.
Which one of the following adrenoceptors decreases cAMP in the post-synaptic target after stimulation with norepinephrine?
- 1α1
- 2α2
- 3β1
- 4β2
Show answer and solution
Answer: (2) α2
α2-adrenoceptors couple to Gi, which inhibits adenylyl cyclase and lowers cAMP. α1 receptors use Gq (IP3, DAG and Ca2+). β1 and β2 receptors use Gs and raise cAMP.
If TLR2 is knocked out from human monocyte-derived macrophages, PAMP recognition by which one of the following TLRs will most probably get affected?
- 1TLR9
- 2TLR3
- 3TLR6
- 4TLR5
Show answer and solution
Answer: (3) TLR6
TLR2 does not work alone. It forms heterodimers with TLR1 (recognising triacyl lipopeptides) and TLR6 (diacyl lipopeptides and zymosan). Without TLR2, PAMP recognition through TLR6 (and TLR1) fails. TLR3 (dsRNA), TLR5 (flagellin) and TLR9 (CpG DNA) signal on their own.
Phosphatidylinositol (PI) is unusual among membrane lipids because it can undergo reversible phosphorylation at multiple sites on the inositol head to generate a variety of phosphorylated PI lipids called phosphoinositides. In a cell signaling event, the enzyme that directly converts PI(4,5)P2 to PI(3,4,5)P3 is:
- 1PI3-Kinase
- 2PLCβ
- 3PTEN
- 4Protein Kinase B
Show answer and solution
Answer: (1) PI3-Kinase
Class I PI3-kinase phosphorylates the 3-position of PI(4,5)P2 to make PI(3,4,5)P3. This recruits PDK1 and Akt (PKB) to the membrane through their PH domains. PTEN reverses the reaction. PLCβ instead cleaves PI(4,5)P2 into IP3 and DAG.
The CaM Kinase II acts as a molecular memory device as well as a frequency decoder of Ca2+ oscillation. Which one of the following statements regarding CaM Kinase II is INCORRECT?
- 1CaM Kinase II activity increases as a function of Ca2+ pulse frequency.
- 2CaM Kinase II requires Ca2+ and Calmodulin to remain in an active state.
- 3A brain-specific CaM Kinase II knockout mouse will have difficulty in remembering where things are.
- 4The molecular memory function is lost in an autophosphorylation defective CaM Kinase II.
Show answer and solution
Answer: (2) CaM Kinase II requires Ca2+ and Calmodulin to remain in an active state.
Statement 2 is the incorrect one. After Ca2+/calmodulin activates neighbouring subunits of the CaMKII holoenzyme, they autophosphorylate Thr286. This makes the kinase partly active without Ca2+/calmodulin, the “molecular memory” that is lost in a T286A mutant. The more frequent the Ca2+ pulses, the more subunits become autophosphorylated, so the kinase decodes frequency. Knockout mice have spatial-learning deficits.
Which one of the following pathogens does not have the ability to survive within macrophages?
- 1Schistosoma mansoni
- 2Mycobacterium tuberculosis
- 3Listeria monocytogenes
- 4Leishmania donovani
Show answer and solution
Answer: (1) Schistosoma mansoni
M. tuberculosis blocks phagosome–lysosome fusion, Listeria escapes into the cytosol using listeriolysin O, and Leishmania survives inside the acidic phagolysosome. All three live inside macrophages. Schistosoma mansoni is a multicellular blood fluke, far too large to be engulfed. It avoids immunity by coating itself in host molecules.
A patient was injected with Purified Protein Derivative (PPD) to diagnose TB disease or a previous exposure to Mycobacterium tuberculosis. The injected area, when inspected after 48-72 hours was found to develop induration (thick, hardened bulge). Which of the following cells will be predominant at this site?
- 1Neutrophils and mast cells
- 2Helper T cells and macrophages
- 3Eosinophils and mast cells
- 4Natural killer and dendritic cells
Show answer and solution
Answer: (2) Helper T cells and macrophages
The tuberculin (Mantoux) reaction is type IV, delayed-type hypersensitivity. Memory TH1 cells recognise the PPD antigens and release IFN-γ and other cytokines, which bring in and activate macrophages. Their accumulation over 48–72 hours produces the induration. Neutrophils, mast cells and eosinophils drive faster or different reactions.
All 95 Cell Signalling and Immunology questions, by subtopic
Each link opens the question on its full paper page. Press Show answer and solution there to see NTA’s final key and a worked solution.
Innate & Adaptive Immunity (35 questions)
| Paper and question | Part | Question |
|---|---|---|
| Jun 2025, Q99 | C | Lab-grown cells of a tumor (Wild type) expressing a novel cancer antigen, and a variant of the same tumor that has lost MHC class I… |
| Jun 2025, Q130 | C | A child injures his toe, which then becomes infected with Staphylococcus aureus. The following statements are made about the events that… |
| Dec 2024 S1, Q51 | B | Which one of the following statements about peripheral lymph nodes is INCORRECT? |
| Dec 2024 S1, Q59 | B | Live vaccines are generally used to protect against which one of the following viruses? |
| Dec 2024 S1, Q89 | C | In an experiment, FITC-CD4 and PE-CD8 were used to stain thymocytes. The cells were then run through a flow cytometer and the data were… |
| Dec 2024 S1, Q99 | C | Lethally irradiated mice were split into 4 groups and experiments were conducted as described below: Group 1 was not given any cells. Group… |
| Dec 2024 S2, Q40 | B | Column X lists Pattern Recognition Receptors (PRRs) and Column Y lists the ligands that bind to the PRRs. Which one of the following… |
| Dec 2024 S2, Q44 | B | Sheep RBCs (SRBCs) were added in wells 1-10 of a micro-titre plate as shown in the figure below. Next, serum from a mouse that had been… |
| Dec 2024 S2, Q53 | B | Which one of the following is NOT required for isotype switching from IgM to IgE? |
| Dec 2024 S2, Q121 | C | The following statements were made about the alternative pathway of Complement activation in the immune system: Which one of the following… |
| Dec 2024 S2, Q136 | C | T cell precursors that exit the bone marrow undergo positive and negative selection in the thymus before emerging as mature T cells. These… |
| Jun 2024 S1, Q34 | B | It was found that most people who were vaccinated with the ancestral strain of Covid-19 (Wuhan strain) were protected against the Delta… |
| Jun 2024 S1, Q38 | B | Which one of the following statements regarding mammalian innate immunity is INCORRECT? |
| Jun 2024 S1, Q114 | C | One hundred IgM+ B cells were plated at 1 cell/well and activated in vitro. This led to detectable proliferation in all wells by day four… |
| Jun 2024 S1, Q124 | C | Four groups of students (A – D) were asked to determine whether memory B cells generated in mice immunized with ovalbumin (OVA), in… |
| Jun 2024 S2, Q25 | B | In the thymus of a normal mouse, positive selection of T cells is based on recognition of which of the following? |
| Jun 2024 S2, Q67 | B | The immune recognition of “self-molecules” is important for which of the following events? |
| Jun 2024 S2, Q73 | C | The following statements are made about how CD4 T cells provide help to CD8 T cells. Which one of the following options represents the… |
| Jun 2024 S2, Q142 | C | The following statements are made about the killing of virus-infected respiratory epithelial cells by cytotoxic T cells: Which one of the… |
| Dec 2023 S1, Q94 | C | In an experiment using nude mice, the population is divided into two groups, A and B. Group A mice are injected with T cells from normal… |
| Dec 2023 S1, Q137 | C | Unknown antigens can be detected or measured by a sandwich ELISA whereas Elispot assays measure the number of cells capable of secreting… |
| Dec 2023 S2, Q36 | B | Which one of the following statements is a characteristic property of B cell epitopes on a protein? |
| Dec 2023 S2, Q66 | B | Which one of the following is the major antibody in the early stages of a primary immune response? |
| Dec 2023 S2, Q92 | C | Apart from the interaction of antigenic peptide with the TCR-CD3 complex (signal 1), T-cell activation requires another signal termed as… |
| Dec 2023 S2, Q93 | C | The following steps/events represent the pathway of presenting extracellular pathogen to cytotoxic T cells: Which one of the following… |
| Jun 2023 S1, Q67 | B | A patient was injected with Purified Protein Derivative (PPD) to diagnose TB disease or a previous exposure to Mycobacterium tuberculosis… |
| Jun 2023 S1, Q89 | C | Following statements are made regarding the roles of complement components in immunity: Which of the following options represents the… |
| Jun 2023 S2, Q35 | B | Which one of the following mechanisms permits immunoglobulin to be synthesized in either a membrane-bound or secreted form? |
| Feb 2022 S1, Q90 | C | The population that is at highest risk against influenza infection should be immunized annually. Which one of the following is the most… |
| Feb 2022 S1, Q94 | C | Which of the following is/are associated with the presentation of endogenous antigens by Class I MHC molecule by an Antigen Presenting Cell… |
| Feb 2022 S1, Q143 | C | Which one of the statements given below regarding generation of monoclonal antibodies is INCORRECT? |
| Feb 2022 S2, Q33 | B | If TLR2 is knocked out from human monocyte-derived macrophages, PAMP recognition by which one of the following TLRs will most probably get affected? |
| Feb 2022 S2, Q89 | C | Bone marrow cells were sorted using 4 cell-surface markers, CD45R (B220), CD43 (leukosialin), membrane-associated Immunoglobulin M (mIgM)… |
| Feb 2022 S2, Q90 | C | Virus infected cells are cleared by cytolysis by natural killer (NK) cells and CD8+ Cytotoxic T lymphocytes (CTLs). Which of the following… |
| Feb 2022 S2, Q137 | C | A researcher raised antibodies against sheep red blood cells (SRBCs) and purified the IgG fraction. Some of the IgG antibodies were then… |
Cell Signalling (32 questions)
| Paper and question | Part | Question |
|---|---|---|
| Jun 2025, Q51 | B | The heterotrimeric G-protein signaling component that is uniquely present in the plant lineage is |
| Dec 2024 S1, Q36 | B | The CaM Kinase II acts as a molecular memory device as well as a frequency decoder of Ca2+ oscillation. Which one of the following… |
| Dec 2024 S1, Q134 | C | The insulin receptor is a receptor tyrosine kinase that engages the PI3 kinase pathway to regulate a FOXO transcription factor. A student… |
| Dec 2024 S2, Q101 | C | Wnt/β-catenin signaling plays essential roles during development. The following statements are made about the Wnt/β-catenin signaling… |
| Jun 2024 S1, Q90 | C | Overexpression of protein ‘A’ in the brain of Drosophila melanogaster causes the degradation of ovaries in the animal. Overexpression of a… |
| Jun 2024 S1, Q127 | C | The inhibitory IκBα protein binds to the NFκB dimer and holds them in an inactive state. On TNF treatment, the IκBα protein is degraded and… |
| Jun 2024 S1, Q138 | C | Given below are protein domains and their binding specificities. Which one of the following options represents all correct matches between… |
| Jun 2024 S2, Q63 | B | Which one of the following adrenoceptors decreases cAMP in the post-synaptic target after stimulation with norepinephrine? |
| Jun 2024 S2, Q84 | C | A receptor tyrosine kinase (RTK) dimerizes and autophosphorylates in presence of a ligand. A researcher prepares three constructs that… |
| Dec 2023 S1, Q34 | B | Phosphatidylinositol (PI) is unusual among membrane lipids because it can undergo reversible phosphorylation at multiple sites on the… |
| Dec 2023 S1, Q35 | B | Column X represents the type of junctions and column Y represents the proteins associated with the junctions. Which one of the following… |
| Dec 2023 S1, Q90 | C | The cAMP-PKA-CREB pathway regulates many important biological processes, from hormone synthesis to inducing long-term memory in the brain… |
| Dec 2023 S2, Q34 | B | Many signal transduction pathways work as molecular switches. On receiving a signal, they switch from an inactive form to an active form… |
| Dec 2023 S2, Q90 | C | The table below summarizes various Hormones (in Column X) and induced cell responses mediated by them via Cyclic AMP (in Column Y). Match… |
| Dec 2023 S2, Q94 | C | G-protein-coupled receptors (GPCRs) form the largest family of cell surface receptors. The GPCRs activate G proteins. G proteins are… |
| Dec 2023 S2, Q96 | C | The insulin receptor is activated on binding insulin molecules. This leads to the activation of the downstream PI3K pathway that triggers… |
| Jun 2023 S1, Q35 | B | The extracellular domain of a cell surface receptor (A) was switched with the extracellular domain of another receptor (B) to create a… |
| Jun 2023 S1, Q80 | C | In the context of signaling, the enzyme protein kinase C (PKC) depends on multiple molecules for its complete activation. This activation… |
| Jun 2023 S1, Q90 | C | Some ligands/stimuli that operate through G protein-coupled receptors (GPCRs) are listed in column X, and the most common effectors through… |
| Jun 2023 S1, Q91 | C | The cycling of monomeric G proteins, such as Ras, between active and inactive states is aided by accessory proteins that bind to the G… |
| Jun 2023 S1, Q92 | C | The following patterns of gene expression were obtained after activating Notch1 receptor with two different ligands Dll1, and Dll4. Which… |
| Jun 2023 S1, Q93 | C | ERK5 is a MAP kinase that is activated upon phosphorylation by MEK5. MEK5 binds with MEKK2 when co-expressed. HEK293 cells were transfected… |
| Jun 2023 S2, Q33 | B | In response to a Wnt signal, β-catenin enters the nucleus and binds to the LEF1/TCF proteins by displacing which one of the following proteins? |
| Jun 2023 S2, Q34 | B | Which one of the following statements regarding ligand identity and effector dynamics is typically correct? |
| Jun 2023 S2, Q90 | C | Two protein kinases, K1 and K2, regulate an intracellular pathway in response to the extracellular signal. The following observations were… |
| Jun 2023 S2, Q93 | C | The figure below represents the data from immunoblots (IB) of co-immunoprecipitation (IP) experiments with antibodies as indicated, after… |
| Feb 2022 S1, Q35 | B | The cytoplasmic domain of the receptor of which of the following proteins does NOT function as tyrosine kinase? |
| Feb 2022 S1, Q91 | C | Localized increases in the cytosolic level of free Ca2+ are critical to its function as second messenger. Calmodulin, a small cytosolic… |
| Feb 2022 S2, Q34 | B | With reference to the signaling pathway shown above, which one of the following options correctly identifies the intracellular components? |
| Feb 2022 S2, Q35 | B | Nitric oxide (NO) acts as intracellular second messenger by stimulating |
| Feb 2022 S2, Q78 | C | Sequencing of the human genome has identified 67 putative gene encoding K+ channels. To characterize the function of one of these genes, a… |
| Feb 2022 S2, Q93 | C | Although a majority of G protein-coupled receptors (GPCRs) act through adenylyl cyclase, many of them (GPCR) exert their effects by… |
Cancer (15 questions)
| Paper and question | Part | Question |
|---|---|---|
| Jun 2025, Q49 | B | Which one of the following statements about human papillomavirus is correct? |
| Jun 2025, Q117 | C | Human prostate cancer cells expressing urokinase Plasminogen Activator (uPA) readily metastasize when injected into experimental animals. A… |
| Dec 2024 S1, Q46 | B | Fill in the blanks: Glioblastomas, oligodendrogliomas, and astrocytomas harbour mutations in isocitrate dehydrogenase (IDH). The IDH… |
| Dec 2024 S2, Q22 | B | Haploinsufficiency in tumor suppressor genes can be caused by all of the following mechanisms EXCEPT |
| Dec 2024 S2, Q79 | C | Breast cancer stem cells may be identified by analyzing the CD24/CD44 phenotype of a breast tumor. CD24/CD44 stained cells were analyzed by… |
| Dec 2024 S2, Q96 | C | The following statements are made regarding the role of tumour microenvironment directly contributing to the metastatic process: Which one… |
| Jun 2024 S1, Q106 | C | A cancer clinic is treating four unrelated patients suffering from chronic myelogenous leukemia. A researcher sequences the Philadelphia… |
| Jun 2024 S2, Q44 | B | Normal human fibroblasts, cancer cells (that originated in stem cells) and fibroblasts transduced with hTERT (hTERT cells) were passaged… |
| Jun 2024 S2, Q124 | C | A cancer cell line obtained from a rat glioma tumour was stained with the nuclear dye Hoechst 33342 and sorted using FACS. About 0.4% of… |
| Dec 2023 S1, Q36 | B | Kaposi’s sarcoma is caused by |
| Dec 2023 S2, Q91 | C | Changes in cancer-critical genes/proteins in different human tumours were analyzed. Gene amplification or deregulation leads to increased… |
| Jun 2023 S2, Q92 | C | The following experiment was designed to establish the synergy of Bcl2 with genes like Myc in leading to B-cell lymphomas. Identify the… |
| Feb 2022 S1, Q36 | B | Tumors are generally classified by |
| Feb 2022 S1, Q37 | B | A breakthrough in cancer therapy is expected where T- cells are taken from a patient are modified in the laboratory to attack cancer cells… |
| Feb 2022 S2, Q91 | C | The gradient of oxygen available to cells at inner regions of a tumour tissue environment is typically low that creates a hypoxic… |
Host–Parasite Interactions (13 questions)
| Paper and question | Part | Question |
|---|---|---|
| Dec 2024 S1, Q115 | C | The statements below are made about some animal pathogens that may evade innate and inflammatory responses by the following mechanisms… |
| Jun 2024 S1, Q98 | C | Which one of the following options represents all correct matches between Column X and Column Y? |
| Jun 2024 S2, Q69 | B | When E. coli and macrophages are placed in a petri dish with medium, the macrophages internalize the E. coli into cytoplasmic vesicles… |
| Dec 2023 S1, Q33 | B | Choose the INCORRECT statement: |
| Dec 2023 S1, Q89 | C | Bacteria employ various mechanisms to invade or enter host cells, which are either phagocytic or non-phagocytic in nature. Given below are… |
| Dec 2023 S2, Q33 | B | Which one of the following statements about Anthrax is correct? |
| Dec 2023 S2, Q89 | C | Column X enlists some of the common animal viruses and column Y enlists cell surface proteins that serve as their receptors. Which one of… |
| Jun 2023 S1, Q33 | B | The mode of action of cholera toxin in causing diarrhoea is by: |
| Jun 2023 S1, Q36 | B | Appressorium is expected to be formed during which one of the following diseases? |
| Jun 2023 S2, Q89 | C | Given below is the list of viruses in Column X and their receptors in human host cells in Column Y. Which one of the following options… |
| Feb 2022 S1, Q34 | B | Which of the following is the causative agent of filariasis? |
| Feb 2022 S2, Q36 | B | Which one of the following pathogens does not have the ability to survive within macrophages? |
| Feb 2022 S2, Q92 | C | Column “X” represents a list of different viruses and column “Y” represents the mechanisms generally adopted by viruses to evade host… |
PYQs for every CSIR-NET unit
How to revise Cell Signalling and Immunology with these questions
- Start with the two biggest subtopicsInnate & Adaptive Immunity and Cell Signalling are where most of the marks have been. Revise them first.
- Attempt before you readWork through a subtopic’s questions on paper, then check them against the answer keys.
- Find the repeatsThe same ideas keep coming back in new wording. When you get one wrong, look for its earlier version in the list above.
- Finish with a full paperTake a whole paper in live exam mode to practise choosing which Part C questions to attempt.
Keep going
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p class=”lbq-src”>Source: CSIR-NET Life Sciences question papers and final answer keys, National Testing Agency, February 2022 to June 2025. Subtopic tags, difficulty ratings and solutions: Lesson Basket.
